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PF4 derived
General Information
DCTPep ID DCTPep04952
Peptide Name PF4 derived
Sequence NGRKISLDLRAPLYKKIIKKLLES
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin PF4
Type Synthetic peptide
Classification
Cancer targeted peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target VEGF FGF2
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C128H226N36O33
Absent amino acids CFHMQTVW
Theoretical pI 10.29
Acidic residues 2
Basic residues 7
Polar residues 5
Molecular weight (Average) 2797.42
Molecular weight (Monoisotopic) 2795.71
Common amino acids KL
Net charge 5
Instability index (II) 13.25
Aliphatic index 134.17
Grand average of hydropathicity (GRAVY) -0.400
Half Life
1.4 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.533
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21470139
Title Anti-angiogenic peptides for cancer therapeutics
Doi 10.2174/138920111796117300
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.