This work is licensed under a Creative Commons Attribution 4.0 International License.
Tetrastatin-2
General Information
DCTPep ID DCTPep05015
Peptide Name Tetrastatin-2
Sequence TLPFAYCNIHQVCHYAQRNDRSYWL
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Homo sapiens (α4 CIV)
Type Synthetic peptide
Classification
Cancer targeted peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target αvβ3
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Not available
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C140H200N40O37S2
Absent amino acids EGKM
Theoretical pI 7.78
Acidic residues 1
Basic residues 4
Polar residues 9
Molecular weight (Average) 3099.49
Molecular weight (Monoisotopic) 3097.44
Common amino acids Y
Net charge 3
Instability index (II) 104.88
Aliphatic index 66.40
Grand average of hydropathicity (GRAVY) -0.524
Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 10095
Abs 0.1% (=1 g/l) 3.257, assuming all pairs of Cys residues form cystines
Ext. coefficient 9970
Abs 0.1% (=1 g/l) 3.217, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18780781
Title A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells
Year 2008
Literature 2
Pubmed ID 21470139
Title Anti-angiogenic peptides for cancer therapeutics
Doi 10.2174/138920111796117300
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.