KV11

General Information


DCTPep ID  DCTPep05049

Peptide Name   KV11

Sequence  YTMNPRKLFDY

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Kringle 5

Type  Synthetic peptide

Classification

  

Cancer targeted peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  cSrc ERK

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C67H98N16O18S1

Absent amino acids  ACEGHIQSVW

Theoretical pI  8.50

Acidic residues  1

Basic residues  2

Polar residues  4

Molecular weight (Average)  1447.67

Molecular weight (Monoisotopic)  1446.7

Common amino acids  Y

Net charge  1

Instability index (II)  -4.6

Aliphatic index  35.45

Grand average of hydropathicity (GRAVY)  -1.073

Half Life 
  2.8 hours (mammalian reticulocytes, in vitro).
  10 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 2980
  Abs 0.1% (=1 g/l) 2.058

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 19515999

Title  Inhibition of pathologic retinal neovascularization by a small peptide derived from human apolipoprotein(a)

Doi 10.1167/iovs.08-3163

Year  2009

Literature 2

Pubmed ID 21470139

Title  Anti-angiogenic peptides for cancer therapeutics

Doi 10.2174/138920111796117300

Year  2011

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.