This work is licensed under a Creative Commons Attribution 4.0 International License.
KV11
General Information
DCTPep ID DCTPep05049
Peptide Name KV11
Sequence YTMNPRKLFDY
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Kringle 5
Type Synthetic peptide
Classification
Cancer targeted peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target cSrc ERK
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C67H98N16O18S1
Absent amino acids ACEGHIQSVW
Theoretical pI 8.50
Acidic residues 1
Basic residues 2
Polar residues 4
Molecular weight (Average) 1447.67
Molecular weight (Monoisotopic) 1446.7
Common amino acids Y
Net charge 1
Instability index (II) -4.6
Aliphatic index 35.45
Grand average of hydropathicity (GRAVY) -1.073
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 2980
Abs 0.1% (=1 g/l) 2.058
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19515999
Title Inhibition of pathologic retinal neovascularization by a small peptide derived from human apolipoprotein(a)
Year 2009
Literature 2
Pubmed ID 21470139
Title Anti-angiogenic peptides for cancer therapeutics
Doi 10.2174/138920111796117300
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.