This work is licensed under a Creative Commons Attribution 4.0 International License.
Ala52 substitution mutant of Tat (49-57)
General Information
DCTPep ID DCTPep05064
Peptide Name Ala52 substitution mutant of Tat (49-57)
Sequence RKKARQRRR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Protein derived
Type Native peptide
Classification
Cancer targeted peptides Membrane-targeted Cell-penetrating peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Penetrating Jurkat
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification fluorescein with 6-aminohexanoic acid (Ahx) spacer
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C50H99N27O11
Absent amino acids CDEFGHILMNPSTVWY
Theoretical pI 12.60
Acidic residues 0
Basic residues 7
Polar residues 0
Molecular weight (Average) 1254.51
Molecular weight (Monoisotopic) 1253.8
Common amino acids R
Net charge 7
Instability index (II) 157.58
Aliphatic index 11.11
Grand average of hydropathicity (GRAVY) -3.556
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11087855
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US6593292B1
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
Cppsite ID 1017
This work is licensed under a Creative Commons Attribution 4.0 International License.