Peptide Libraray

Ala substitution mutant of Tat (48-60)

General Information

DCTPep ID DCTPep05075

Peptide Name Ala substitution mutant of Tat (48-60)

Sequence GRKKRRQARAPPQC

Sequence Length 14

UniProt ID Not available

PubChem CID Not available

Origin Protein derived

Type Native peptide

Classification

Cancer targeted peptides Membrane-targeted Cell-penetrating peptides

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Penetrating HeLa

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Fluorescein

Other Modification None

Chiral L

Physicochemical Information

Formula C67H122N30O17S1

Absent amino acids DEFHILMNSTVWY

Theoretical pI 12.01

Acidic residues 0

Basic residues 6

Polar residues 2

Molecular weight (Average) 1651.96

Molecular weight (Monoisotopic) 1650.93

Common amino acids R

Net charge 6

Instability index (II) 123.13

Aliphatic index 14.29

Grand average of hydropathicity (GRAVY) -2.164

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

Cppsite ID 1028