Ala substitution mutant of Tat (48-60)

General Information


DCTPep ID  DCTPep05075

Peptide Name   Ala substitution mutant of Tat (48-60)

Sequence  GRKKRRQARAPPQC

Sequence Length  14

UniProt ID  Not available

PubChem CID  Not available

Origin  Protein derived

Type  Native peptide

Classification

  

Cancer targeted peptides Membrane-targeted Cell-penetrating peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Penetrating HeLa



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Fluorescein

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C67H122N30O17S1

Absent amino acids  DEFHILMNSTVWY

Theoretical pI  12.01

Acidic residues  0

Basic residues  6

Polar residues  2

Molecular weight (Average)  1651.96

Molecular weight (Monoisotopic)  1650.93

Common amino acids  R

Net charge  6

Instability index (II)  123.13

Aliphatic index  14.29

Grand average of hydropathicity (GRAVY)  -2.164

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
  Ext. coefficient 0
  Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




Cppsite ID  1028

DCTPep is developed by Dr.Zheng's team.