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Reduced linear penetratin
General Information
DCTPep ID DCTPep05112
Peptide Name Reduced linear penetratin
Sequence CRQIKIWFPNRRMKWKKC
Sequence Length 18
UniProt ID Not available
PubChem CID 45029001
Origin Protein derived
Type Native peptide
Classification
Cancer targeted peptides Membrane-targeted Cell-penetrating peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Penetrating HaCat/ A549 cells
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Biotinylation (Labeled with Biotinyl-Ahx)
C-terminal Modification Unknown
Other Modification None
Chiral L
Physicochemical Information
Formula C110H177N35O21S3
Absent amino acids ADEGHLSTVY
Theoretical pI 11.08
Acidic residues 0
Basic residues 7
Polar residues 3
Molecular weight (Average) 2422.02
Molecular weight (Monoisotopic) 2420.3
Common amino acids K
Net charge 7
Instability index (II) 53.23
Aliphatic index 43.33
Grand average of hydropathicity (GRAVY) -1.156
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11125
Abs 0.1% (=1 g/l) 4.593, assuming all pairs of Cys residues form cystines
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 4.542, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10784032
Title Not available
Doi Not available
Year Not available
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
Cppsite ID 1131
This work is licensed under a Creative Commons Attribution 4.0 International License.