This work is licensed under a Creative Commons Attribution 4.0 International License.
Lyp-1
General Information
DCTPep ID DCTPep05198
Peptide Name Lyp-1
Sequence CGNKRTRGC
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Membrane-targeted Cell-penetrating peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Penetrating MDA-MB-435 cells
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification fluorescein
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C36H67N17O12S2
Absent amino acids ADEFHILMPQSVWY
Theoretical pI 9.70
Acidic residues 0
Basic residues 3
Polar residues 6
Molecular weight (Average) 994.15
Molecular weight (Monoisotopic) 993.46
Common amino acids CGR
Net charge 3
Instability index (II) 52.56
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -1.433
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.126, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15197262
Title Not available
Doi Not available
Year Not available
Patent
Patent ID US7192921B2
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
Cppsite ID 1504
This work is licensed under a Creative Commons Attribution 4.0 International License.