This work is licensed under a Creative Commons Attribution 4.0 International License.
Alexa488-Melan-A-TAT
General Information
DCTPep ID DCTPep05504
Peptide Name Alexa488-Melan-A-TAT
Sequence CELAGIGILTVRKKRRQRRR
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Chimeric
Type Native peptide
Classification
Cancer targeted peptides Membrane-targeted Cell-penetrating peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Penetrating DCs, HUVECs and Jurkat cells
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Conjugation with Alexa488 C5 maleimide
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C101H189N41O25S1
Absent amino acids DFHMNPSWY
Theoretical pI 12.01
Acidic residues 1
Basic residues 8
Polar residues 4
Molecular weight (Average) 2409.93
Molecular weight (Monoisotopic) 2408.45
Common amino acids R
Net charge 7
Instability index (II) 122.49
Aliphatic index 97.50
Grand average of hydropathicity (GRAVY) -0.910
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24372650
Title Not available
Doi Not available
Year Not available
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
Cppsite ID 2335
This work is licensed under a Creative Commons Attribution 4.0 International License.