MCoTI-M5

General Information


DCTPep ID  DCTPep05595

Peptide Name   MCoTI-M5

Sequence  GGVCPRILRRCRRDSDCPGACICRGNGYCGSGSK

Sequence Length  34

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Membrane-targeted Cell-penetrating peptides



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Penetrating HeLa



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys4<--->Cys21; Cys11<--->Cys23; Cys11<--->Cys29; NCB: Gly1<--->Asp34

N-terminal Modification  Conjugation with Alexa Flour 488

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C140H238N54O44S6

Absent amino acids  EFHMQTW

Theoretical pI  9.21

Acidic residues  2

Basic residues  7

Polar residues  18

Molecular weight (Average)  3574.13

Molecular weight (Monoisotopic)  3571.64

Common amino acids  G

Net charge  5

Instability index (II)  71.65

Aliphatic index  45.88

Grand average of hydropathicity (GRAVY)  -0.509

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1865
  Abs 0.1% (=1 g/l) 0.522, assuming all pairs of Cys residues form cystines
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 0.417, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24985034

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




Cppsite ID  2457

DCTPep is developed by Dr.Zheng's team.