This work is licensed under a Creative Commons Attribution 4.0 International License.
MCoTI-M5
General Information
DCTPep ID DCTPep05595
Peptide Name MCoTI-M5
Sequence GGVCPRILRRCRRDSDCPGACICRGNGYCGSGSK
Sequence Length 34
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Membrane-targeted Cell-penetrating peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Penetrating HeLa
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys21; Cys11<--->Cys23; Cys11<--->Cys29; NCB: Gly1<--->Asp34
N-terminal Modification Conjugation with Alexa Flour 488
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C140H238N54O44S6
Absent amino acids EFHMQTW
Theoretical pI 9.21
Acidic residues 2
Basic residues 7
Polar residues 18
Molecular weight (Average) 3574.13
Molecular weight (Monoisotopic) 3571.64
Common amino acids G
Net charge 5
Instability index (II) 71.65
Aliphatic index 45.88
Grand average of hydropathicity (GRAVY) -0.509
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1865
Abs 0.1% (=1 g/l) 0.522, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.417, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24985034
Title Not available
Doi Not available
Year Not available
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
Cppsite ID 2457
This work is licensed under a Creative Commons Attribution 4.0 International License.