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N-terminus of X-Pep
General Information
DCTPep ID DCTPep05758
Peptide Name N-terminus of X-Pep
Sequence MAARLCCQLDPARDVLCLRP
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Protein derived
Type Native peptide
Classification
Cancer targeted peptides Membrane-targeted Cell-penetrating peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Penetrating Hepg2 cells
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H162N30O26S4
Absent amino acids EFGHIKNSTWY
Theoretical pI 7.74
Acidic residues 2
Basic residues 3
Polar residues 3
Molecular weight (Average) 2244.73
Molecular weight (Monoisotopic) 2243.12
Common amino acids L
Net charge 1
Instability index (II) 50.42
Aliphatic index 107.50
Grand average of hydropathicity (GRAVY) 0.350
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.056, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25251474
Title X-pep, a novel cell-penetrating peptide motif derived from the hepatitis B virus
Doi 10.1016/j.bbrc.2014.09.057
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
Cppsite ID 2901
This work is licensed under a Creative Commons Attribution 4.0 International License.