This work is licensed under a Creative Commons Attribution 4.0 International License.
Alyteserin-2a-Sp1
General Information
DCTPep ID DCTPep05876
Peptide Name Alyteserin-2a-Sp1
Sequence ILGKLLⓍTAAⓍLLSNL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Stapled Peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | IC50=1.6μM | CCK-8 assay | 72h | Patent |
| A549 | Lung adenocarcinoma | IC50=3.6±1.0 μM | CCK-8 assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=4.9±0.91 μM | CCK-8 assay | 72 h | 1 |
| U87 | Glioblastoma | IC50=9.8±0.11 μM | CCK-8 assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity 48.3
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ are cross-linked by hydrocarbon stapling
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine (S5)
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34989078
Title Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents
Doi 10.1002/psc.3401
Year 2022
Patent
Patent ID CN115160406A
Patent Title Preparation method and application of novel anti-tumor cyclic peptide active molecules
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.