Alyteserin-2a-Sp3

General Information


DCTPep ID  DCTPep05878

Peptide Name   Alyteserin-2a-Sp3

Sequence  ILGKLLSTAⓍGLLⓍNL

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides Stapled Peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma IC50=0.86μM CCK-8 assay 72h Patent
MCF-7 Invasive breast carcinoma of no special type IC50=0.99±0.21 μM CCK-8 assay 72 h 1
A549 Lung adenocarcinoma IC50=2.8±0.90 μM CCK-8 assay 72 h 1
U87 Glioblastoma IC50=3.9±0.010 μM CCK-8 assay 72 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  80.1

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ are cross-linked by hydrocarbon stapling

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  Ⓧ=(S)-2-(4-pentenyl)alanine (S5)

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 34989078

Title  Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents

Doi 10.1002/psc.3401

Year  2022

Patent

Patent ID CN115160406A

Patent Title  Preparation method and application of novel anti-tumor cyclic peptide active molecules

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.