A4K14-citropin1.1-Sp4

General Information


DCTPep ID  DCTPep05891

Peptide Name   A4K14-citropin1.1-Sp4

Sequence  GLFAVIKKⓍASVⓍKGL

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides Stapled Peptides Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type IC50=10.49 μM CCK-8 assay 96 h 1
A549 Lung adenocarcinoma IC50=10.51 μM CCK-8 assay 96 h 1
U87 Glioblastoma IC50=7.277 μM CCK-8 assay 96 h 1
C4-2B Prostate carcinoma IC50=8.90 μM CCK-8 assay 96 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  85.3

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ are cross-linked by hydrocarbon stapling

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Ⓧ=(S)-2-(4-pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33363118

Title  Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides

Doi 10.3389/fchem.2020.616147

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.