This work is licensed under a Creative Commons Attribution 4.0 International License.
PEG-DOX-E-[c(RGDfK)2]
General Information
DCTPep ID DCTPep05900
Peptide Name PEG-DOX-E-[c(RGDfK)2]
Sequence XE(RGDfK)(RGDfK)
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Targeted peptide conjugates Antiangiogenic αvβ3 Inhibitor
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| M109S | DOX-sensitive-M109 murine lung carcinoma | IC50=1.2 μM | MTT assay | 72 h | 1 |
| U87 | Glioblastoma | IC50=400 nM | MTT assay | 72 h | 1 |
| M109R | Subline of DOX-sensitive-M109 murine lung carcinoma (M109S) cells | IC50=9 μM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=40 nM
Target αvβ3
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Arg1<--->Lys5
N-terminal Modification PEG, Poly ethylene glycol
C-terminal Modification Free
Other Modification X=DOX, Doxorubicin
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Development of PEGylated doxorubicin-E-[c(RGDfK)2] conjugate for integrin-targeted cancer therapy
Doi 10.1002/pat.1731
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.