ATSP-3848

General Information


DCTPep ID  DCTPep05902

Peptide Name   ATSP-3848

Sequence  LTFEHYWAQLTS

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis MDM2/MDMX Inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  MDM2, MDMX

Affinity  MDM2: Ki=14.6 nM; MDMX: Ki=47.4 nM

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C71H98N16O20

Absent amino acids  CDGIKMNPRV

Theoretical pI  5.24

Acidic residues  1

Basic residues  1

Polar residues  4

Molecular weight (Average)  1495.65

Molecular weight (Monoisotopic)  1494.71

Common amino acids  LT

Net charge  0

Instability index (II)  28.62

Aliphatic index  73.33

Grand average of hydropathicity (GRAVY)  -0.200

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 6990
  Abs 0.1% (=1 g/l) 4.674

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23946421

Title  Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Doi 10.1073/pnas.1303002110

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.