This work is licensed under a Creative Commons Attribution 4.0 International License.
ATSP-3848
General Information
DCTPep ID DCTPep05902
Peptide Name ATSP-3848
Sequence LTFEHYWAQLTS
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis MDM2/MDMX Inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2, MDMX
Affinity MDM2: Ki=14.6 nM; MDMX: Ki=47.4 nM
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H98N16O20
Absent amino acids CDGIKMNPRV
Theoretical pI 5.24
Acidic residues 1
Basic residues 1
Polar residues 4
Molecular weight (Average) 1495.65
Molecular weight (Monoisotopic) 1494.71
Common amino acids LT
Net charge 0
Instability index (II) 28.62
Aliphatic index 73.33
Grand average of hydropathicity (GRAVY) -0.200
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 4.674
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23946421
Title Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.