Peptide Libraray

SPMI1

General Information

DCTPep ID DCTPep05917

Peptide Name SPMI1

Sequence TSFⓍEYWⓍLLS

Sequence Length 11

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Stapled Peptides Induce apoptosis Induce cell cycle arrest MDM6/MDMX Inhibitor

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HCT 116 p53-/-	Colon carcinoma	IC50>100 μM	CCK-8 assay	72 h	1
HCT 116 p53+/+	Colon carcinoma	IC50>100 μM	CCK-8 assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target MDM2, MDMX

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity 4

Linear/Cyclic Cyclic (Stapled)

Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification Ⓧ=S-pentenyl-alanine

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 36185610

Title Design of stapled peptide-based PROTACs for MDM2/MDMX atypical degradation and tumor suppression

Doi 10.7150/thno.75444

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available