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LHP1
General Information
DCTPep ID DCTPep05920
Peptide Name LHP1
Sequence TEFQTNLVP
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Tubulin Inhibitors
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Tubulin
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification FITC, 5(6)-carboxy fluorescence
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C47H73N11O16
Absent amino acids ACDGHIKMRSWY
Theoretical pI 4.00
Acidic residues 1
Basic residues 0
Polar residues 3
Molecular weight (Average) 1048.16
Molecular weight (Monoisotopic) 1047.52
Common amino acids T
Net charge -1
Instability index (II) 34.99
Aliphatic index 75.56
Grand average of hydropathicity (GRAVY) -0.300
Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36240440
Title Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors
Doi 0.1021/acs.jmedchem.2c01116
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.