Peptide Libraray

LHP2

General Information

DCTPep ID DCTPep05921

Peptide Name LHP2

Sequence FRRKAFLHWYTG

Sequence Length 12

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides Induce apoptosis Tubulin Inhibitors

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	IC50=271.59 ± 76.41 μM	MTT assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Tubulin

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond

N-terminal Modification FITC, 5(6)-carboxy fluorescence

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C77H108N22O15

Absent amino acids CDEIMNPQSV

Theoretical pI 11.00

Acidic residues 0

Basic residues 4

Polar residues 3

Molecular weight (Average) 1581.84

Molecular weight (Monoisotopic) 1580.84

Common amino acids FR

Net charge 4

Instability index (II) 40.35

Aliphatic index 40.83

Grand average of hydropathicity (GRAVY) -0.683

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 4.419

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 36240440

Title Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors

Doi 0.1021/acs.jmedchem.2c01116

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available