Peptide Libraray

LHP5

General Information

DCTPep ID DCTPep05924

Peptide Name LHP5

Sequence NEALYDICFR

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Induce apoptosis Tubulin Inhibitors

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Tubulin

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification FITC, 5(6)-carboxy fluorescence

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C55H82N14O17S1

Absent amino acids GHKMPQSTVW

Theoretical pI 4.37

Acidic residues 2

Basic residues 1

Polar residues 3

Molecular weight (Average) 1243.4

Molecular weight (Monoisotopic) 1242.57

Common amino acids ACDEFILNRY

Net charge -1

Instability index (II) 32.68

Aliphatic index 88.00

Grand average of hydropathicity (GRAVY) -0.090

Half Life
1.4 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.198, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.198, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 36240440

Title Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors

Doi 0.1021/acs.jmedchem.2c01116

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available