fStAx-40

General Information


DCTPep ID  DCTPep05948

Peptide Name   fStAx-40

Sequence  XRRWPQⓍILHⓍDVRRVWR

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides β-catenin inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  β-catenin

Affinity  Kd=~4 μM

Mechanism  Inhibit wnt/β-catenin signaling pathway



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling

N-terminal Modification  FITC

C-terminal Modification  Amidation

Other Modification  X=PEG1, [2-(2-aminoethoxy)ethoxy]acetyl; Ⓧ=(S)-2-(4'-pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23071338

Title  Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Doi 10.1073/pnas.1208396109

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.