This work is licensed under a Creative Commons Attribution 4.0 International License.
wtR6IP
General Information
DCTPep ID DCTPep05953
Peptide Name wtR6IP
Sequence DDEKEQFLYHLLSFNAV
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Cell-penetrating peptides Rab8a GTPase inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Rab8a GTPase
Affinity rel.Kd=8.7 (rel.Kd=[Kd(peptide)/ Kd(StRIP3)])*
* Cmax[Rab8a6-176(GppNHp)]=300 µM, Kd(StRIP3)=17.5 µM
Mechanism Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Fluorescein-O2OC-
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H138N22O30
Absent amino acids CGIMPRTW
Theoretical pI 4.31
Acidic residues 4
Basic residues 2
Polar residues 3
Molecular weight (Average) 2068.27
Molecular weight (Monoisotopic) 2066.99
Common amino acids L
Net charge -2
Instability index (II) 23.56
Aliphatic index 91.76
Grand average of hydropathicity (GRAVY) -0.424
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.720
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27336832
Title Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase
Doi 2016
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.