This work is licensed under a Creative Commons Attribution 4.0 International License.
StRIP3
General Information
DCTPep ID DCTPep05954
Peptide Name StRIP3
Sequence DDEⓍEQFⓍYHLLSFNAV
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Cell-penetrating peptides Rab8a GTPase inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Rab8a GTPase
Affinity Kd=30±1 μM
Mechanism Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity 40
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8) are cross-linked by hydrocarbon stapling
N-terminal Modification Fluorescein-O2OC-
C-terminal Modification Free
Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27336832
Title Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase
Doi 2016
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.