Peptide Libraray

StRIP14[D901N,E902Q]

General Information

DCTPep ID DCTPep05979

Peptide Name StRIP14[D901N,E902Q]

Sequence DNQⓍEWFⓍYHLⓍFFNⓍV

Sequence Length 17

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Stapled Peptides Cell-penetrating peptides Rab8a GTPase inhibitor

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Rab8a GTPase

Affinity rel.Kd=0.73 (rel.Kd=[Kd(peptide)/ Kd(StRIP3)])*

* Cmax[Rab8a6-176(GppNHp)]=570 µM, Kd(StRIP3)=64.12 µM

Mechanism Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic (Stapled)

Disulfide/Other Bond Stapled: Ⓧ(4) and Ⓧ (8), Ⓧ(12) and Ⓧ (16) are cross-linked by hydrocarbon stapling

N-terminal Modification Fluorescein-O2OC-

C-terminal Modification Free

Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 27336832

Title Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

Doi 2016

Year

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available