StRIP14[D901N,E902Q]

General Information


DCTPep ID  DCTPep05979

Peptide Name   StRIP14[D901N,E902Q]

Sequence  DNQⓍEWFⓍYHLⓍFFNⓍV

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Cell-penetrating peptides Rab8a GTPase inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Rab8a GTPase

Affinity  rel.Kd=0.73 (rel.Kd=[Kd(peptide)/ Kd(StRIP3)])*

*  Cmax[Rab8a6-176(GppNHp)]=570 µM, Kd(StRIP3)=64.12 µM

Mechanism  Binds Rab8a(GppNHp) and is able to inhibit a Rab8a PPI.



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(4) and Ⓧ (8), Ⓧ(12) and Ⓧ (16) are cross-linked by hydrocarbon stapling

N-terminal Modification  Fluorescein-O2OC-

C-terminal Modification  Free

Other Modification  Ⓧ=(S)-2-(4-pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 27336832

Title  Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase

Doi 2016

Year 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.