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WT p53
General Information
DCTPep ID DCTPep05988
Peptide Name WT p53
Sequence LSQETFSDLWKLLPEN
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Mdm2 inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Mdm2
Affinity Kd=410 nM
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C88H134N20O28
Absent amino acids ACGHIMRVY
Theoretical pI 4.14
Acidic residues 3
Basic residues 1
Polar residues 4
Molecular weight (Average) 1920.15
Molecular weight (Monoisotopic) 1918.97
Common amino acids L
Net charge -2
Instability index (II) 73.56
Aliphatic index 97.50
Grand average of hydropathicity (GRAVY) -0.512
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.864
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22148351
Title Structure of the stapled p53 peptide bound to Mdm2
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.