This work is licensed under a Creative Commons Attribution 4.0 International License.
5
General Information
DCTPep ID DCTPep05998
Peptide Name 5
Sequence FETLRGDLRILSILRⓍQNLⓍKELQD
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic (Derived from chromogranin A)
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides αvβ6/αvβ8 inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target αvβ6, αvβ8
Affinity αvβ6: Ki=0.6 ± 0.1 nM; αvβ8: Ki=3.2 ± 1.2 nM
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(16) and Ⓧ (20) are cross-linked by triazole bridge stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(16)=Propargylglycine; Ⓧ(20)=Azidolysine
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36594095
Title A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins
Year 2023
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.