This work is licensed under a Creative Commons Attribution 4.0 International License.
A20FMDV2
General Information
DCTPep ID DCTPep06001
Peptide Name A20FMDV2
Sequence NAVPNLRGDLQVLAQKVART
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides αvβ6/αvβ8 inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target αvβ6, αvβ8
Affinity αvβ6: Ki=0.9 ± 0.2 nM; αvβ8: Ki=69 ± 0.2 nM
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H163N31O28
Absent amino acids CEFHIMSWY
Theoretical pI 10.84
Acidic residues 1
Basic residues 3
Polar residues 4
Molecular weight (Average) 2163.51
Molecular weight (Monoisotopic) 2162.23
Common amino acids ALV
Net charge 2
Instability index (II) 32.8
Aliphatic index 117.00
Grand average of hydropathicity (GRAVY) -0.185
Half Life
1.4 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36594095
Title A stapled chromogranin A-derived peptide homes in on tumors that express αvβ6 or αvβ8 integrins
Year 2023
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.