This work is licensed under a Creative Commons Attribution 4.0 International License.
MAC-1-Sp2
General Information
DCTPep ID DCTPep06010
Peptide Name MAC-1-Sp2
Sequence GFⓍMALⓍLLKKVL
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Stapled Peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | IC50=0.84μM | CCK-8 assay | 24h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=1.7μM | CCK-8 assay | 24h | Patent |
| HepG2 | Hepatoblastoma | IC50=2.4μM | CCK-8 assay | 24h | Patent |
| U251 | Astrocytoma | IC50=3.6μM | CCK-8 assay | 24h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Chymotrypsin hydrolysis
Affinity Not available
Mechanism Resisting chymotrypsin hydrolysis
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(3) and Ⓧ (7) are cross-linked by hydrocarbon stapling
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification Ⓧ=(2R)-2-amino-2-methyl-6-heptenoic acid
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN113896766A
Patent Title Novel anti-tumor cyclic peptide active molecule, preparation method and application
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.