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TAT-WLP
General Information
DCTPep ID DCTPep06019
Peptide Name TAT-WLP
Sequence FSLNWRPPCLFYGRKKRRQRRR
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Targeted peptide conjugates
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| NCI-H1299 | Lung large cell carcinoma | IC50=14.09μM | MTS assay | 48h | Patent |
| MDA-MB-231 | Breast adenocarcinoma | IC50=16.07μM | MTS assay | 48h | Patent |
| HepG2 | Hepatoblastoma | IC50=16.24μM | MTS assay | 48h | Patent |
| T47D | Invasive breast carcinoma of no special type | IC50=20.3μM | MTS assay | 48h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=7.69μM | MTS assay | 48h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C131H210N48O27S1
Absent amino acids ADEHIMTV
Theoretical pI 12.13
Acidic residues 0
Basic residues 9
Polar residues 5
Molecular weight (Average) 2921.47
Molecular weight (Monoisotopic) 2919.63
Common amino acids R
Net charge 9
Instability index (II) 140.31
Aliphatic index 35.45
Grand average of hydropathicity (GRAVY) -1.691
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.393, assuming all pairs of Cys residues form cystines
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.393, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN114457052A
Patent Title Anti-tumor polypeptide composition and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.