Tempor in-1CEa-Sp11

General Information


DCTPep ID  DCTPep06030

Peptide Name   Tempor in-1CEa-Sp11

Sequence  FVDLKKⓍANIINSⓍFGK

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides Stapled Peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HCT 116 Colon carcinoma IC50=3.55μM CCK-8 assay 96h Patent

Hemolytic Activity  Low hemolysis

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Ⓧ(7)=(2R)-2-amino-2-methyl-6-decanoic acid; Ⓧ(14)=(2R)-2-amino-2-methyl-6-heptenoic acid

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN114605498A

Patent Title  Stapled peptide antineoplastic active compound, pharmaceutical composition and application of stapled peptide antineoplastic active compound

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.