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LXP-7
General Information
DCTPep ID DCTPep06033
Peptide Name LXP-7
Sequence RAGLQFPVGKLLKKLLKKLLK
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| PC-9 | Lung adenocarcinoma | IC50=10.1μM | CCK-8 assay | 72h | Patent |
| HGC-27 | Gastric carcinoma | IC50=3.2μM | CCK-8 assay | 72h | Patent |
| MDA-MB-231 | Breast adenocarcinoma | IC50=4.1μM | CCK-8 assay | 72h | Patent |
| HCT 116 | Colon carcinoma | IC50=4.8μM | CCK-8 assay | 72h | Patent |
| HCT 8 | Colon adenocarcinoma | IC50=6.6μM | CCK-8 assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C115H207N31O23
Absent amino acids CDEHIMNSTWY
Theoretical pI 11.43
Acidic residues 0
Basic residues 7
Polar residues 2
Molecular weight (Average) 2392.1
Molecular weight (Monoisotopic) 2390.6
Common amino acids L
Net charge 7
Instability index (II) 7.46
Aliphatic index 148.57
Grand average of hydropathicity (GRAVY) 0.076
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN114605517A
Patent Title Polypeptide LXP-7 with broad-spectrum anticancer effect and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.