This work is licensed under a Creative Commons Attribution 4.0 International License.
TAT-LP8
General Information
DCTPep ID DCTPep06034
Peptide Name TAT-LP8
Sequence YGRKKRRQRRRLPDWHIPV
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Cancer targeted peptides MDM2 antagonistic
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C112H185N43O24
Absent amino acids ACEFMNST
Theoretical pI 12.01
Acidic residues 1
Basic residues 9
Polar residues 2
Molecular weight (Average) 2517.97
Molecular weight (Monoisotopic) 2516.46
Common amino acids R
Net charge 8
Instability index (II) 173.12
Aliphatic index 56.32
Grand average of hydropathicity (GRAVY) -2.016
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 2.776
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN114634551A
Patent Title Polypeptide and application thereof in preparation of anti-cancer drug for antagonizing combination of wild type p53 and MDM2
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.