Peptide Libraray

DMS-PS1

General Information

DCTPep ID DCTPep06037

Peptide Name DMS-PS1

Sequence GLWKSLFKNVGKAAGKAALNAVTDMVNQ

Sequence Length 28

UniProt ID Not available

PubChem CID Not available

Origin South America frog Phy l lomeduasauvagi

Type Native peptide

Classification

ACP Tumor active peptide Cancer targeted peptides Induce apoptosis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	IC50=11.54μM	MTT assay	24h	Patent
PC-3	Prostate carcinoma	IC50=2.444μM	MTT assay	24h	Patent
U251MG	Astrocytoma	IC50=26.7μM	MTT assay	24h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Inducing PC-3 cell apoptosis

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C131H215N37O37S1

Absent amino acids CEHIPRY

Theoretical pI 10.00

Acidic residues 1

Basic residues 4

Polar residues 8

Molecular weight (Average) 2932.43

Molecular weight (Monoisotopic) 2930.58

Common amino acids A

Net charge 3

Instability index (II) -2.09

Aliphatic index 90.71

Grand average of hydropathicity (GRAVY) 0.036

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 1.876

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID CN114835791A

Patent Title Anticancer peptide DMS-PS1 of South America frog and application thereof

Other Iinformation Not available

Other Published ID Not available