This work is licensed under a Creative Commons Attribution 4.0 International License.
General Information
DCTPep ID DCTPep06040
Peptide Name
Sequence KKCGIQDTNDKKQSD
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Cancer targeted peptides Agonist
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target IGFBP3
Affinity Not available
Mechanism The compound can be used as an agonist to competitively inhibit protein level interaction of PD-L1 and IGFBP3.
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C68H118N22O27S1
Absent amino acids AEFHLMPRVWY
Theoretical pI 8.16
Acidic residues 3
Basic residues 4
Polar residues 5
Molecular weight (Average) 1707.88
Molecular weight (Monoisotopic) 1706.83
Common amino acids K
Net charge 1
Instability index (II) 35.89
Aliphatic index 26.00
Grand average of hydropathicity (GRAVY) -2.100
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN115433287A
Patent Title Small molecule peptide and application thereof as agonist and in anti-cancer drugs
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.