Peptide Libraray

coloy(Trp-Val-Val-Ala-Ile-Phe)

General Information

DCTPep ID DCTPep06042

Peptide Name coloy(Trp-Val-Val-Ala-Ile-Phe)

Sequence WVVAIF

Sequence Length 6

UniProt ID Not available

PubChem CID Not available

Origin Frog fecal mildew

Type Native peptide

Classification

ACP Tumor active peptide Cancer targeted peptides α-Glucosidase inhibitor

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	IC50=96.64μg/ml	CCK-8 assay	Not available	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target α-Glucosidase

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Trp1<--->Phe6

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C39H55N7O7

Absent amino acids CDEGHKLMNPQRSTY

Theoretical pI 5.52

Acidic residues 0

Basic residues 0

Polar residues 0

Molecular weight (Average) 733.91

Molecular weight (Monoisotopic) 733.42

Common amino acids V

Net charge 0

Instability index (II) -5.82

Aliphatic index 178.33

Grand average of hydropathicity (GRAVY) 2.767

Half Life
2.8 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 7.494

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID CN115572324A

Patent Title Cyclochrome-valine-valine-propyl-bright-phenylalanine with hepatoma carcinoma cytotoxicity and alpha-glucosidase inhibitory activity and preparation method of cyclochrome-valine-valine-propyl-bright-phenylalanine

Other Iinformation Not available

Other Published ID Not available