Peptide Libraray

General Information

DCTPep ID DCTPep06064

Peptide Name LK

Sequence LKKLLKLLKKLLKL

Sequence Length 14

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	20% Survival=20μM	MTT assay	24h	Patent

Hemolytic Activity Mouse red blood cells:Hemolysis rate=48%=50μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C84H162N20O15

Absent amino acids ACDEFGHIMNPQRSTVWY

Theoretical pI 10.70

Acidic residues 0

Basic residues 6

Polar residues 0

Molecular weight (Average) 1692.34

Molecular weight (Monoisotopic) 1691.25

Common amino acids L

Net charge 6

Instability index (II) -39.23

Aliphatic index 222.86

Grand average of hydropathicity (GRAVY) 0.500

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID CN110862458A

Patent Title Combined peptide with acid-activated anti-tumor activity and clinical application of combined peptide

Other Iinformation Not available

Other Published ID Not available