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ALK-1
General Information
DCTPep ID DCTPep06065
Peptide Name ALK-1
Sequence CLHELLEHLHELLEHCLKKLLKLLKKLLKL
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Membrane-targeted Targeted peptide conjugates
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | 60% Survival=20μM | MTT assay | 24h | Patent |
Hemolytic Activity Mouse red blood cells:Hemolysis rate=10%=50μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys16
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C170H294N44O39S2
Absent amino acids ADFGIMNPQRSTVWY
Theoretical pI 8.76
Acidic residues 4
Basic residues 10
Polar residues 2
Molecular weight (Average) 3642.6
Molecular weight (Monoisotopic) 3640.18
Common amino acids L
Net charge 6
Instability index (II) -5.16
Aliphatic index 182.00
Grand average of hydropathicity (GRAVY) 0.267
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.034, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN110862458A
Patent Title Combined peptide with acid-activated anti-tumor activity and clinical application of combined peptide
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.