IDP-H14

General Information


DCTPep ID  DCTPep06114

Peptide Name   IDP-H14

Sequence  RVKLVNLⓍFATLREⓍVP

Sequence Length  17

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides Stapled Peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia EC50=14μM MTT assay 24h Patent
GBM-18 Glioblastoma EC50=4μM MTT assay 24h Patent
GBM-27 Glioblastoma EC50=5μM MTT assay 24h Patent
NCI-H69 Lung small cell carcinoma; Small cell lung cancer EC50=7μM MTT assay 24h Patent
MCF-7 Invasive breast carcinoma of no special type EC50=9μM MTT assay 24h Patent

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic(stapled)

Disulfide/Other Bond  Stapled: Ⓧ(8) and Ⓧ (15) are cross-linked by hydrocarbon stapling

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  Ⓧ(8)=2-amino-2-methyl-6-decanoic acid; Ⓧ(15)=2-amino-2-methyl-6-heptenoic acid

Chiral  L



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN111263768A

Patent Title  Anticancer Peptides

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.