This work is licensed under a Creative Commons Attribution 4.0 International License.
IDP-LS15
General Information
DCTPep ID DCTPep06158
Peptide Name IDP-LS15
Sequence RKRRNDLRSⓍFLALRDⓍ
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Cancer targeted peptides Stapled Peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| RPMI | Human multiple myeloma | EC50=7μm | MTT assay | 24h | Patent |
| U266 | Plasma cell myeloma; Multiple myeloma | EC50=8μm | MTT assay | 24h | Patent |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | EC50>100μm | MTT assay | 24h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | EC50>100μm | MTT assay | 24h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic(stapled)
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification Ⓧ(10)=2-amino-2-methyl-6-decanoic acid; Ⓧ(17)=2-amino-2-methyl-9-heptenoic acid
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN111511761A
Patent Title Anticancer Peptides
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.