[R3A/R7A/R10A]GeXIVA[1,2]

General Information


DCTPep ID  DCTPep06217

Peptide Name   [R3A/R7A/R10A]GeXIVA[1,2]

Sequence  TCASSGAYCASPYDRRRRYCRRITDACV

Sequence Length  28

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Cancer targeted peptides α9α10nAChR inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  α9α10nAChR

Affinity  IC50>10000 nM (Blocking α9α10nAChR)

Mechanism  Specifically block the α9α10nAChR



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

SequenceNo structure available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys2<--->Cys9; Cys20<--->Cys27

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C130H210N46O41S4

Absent amino acids  EFHKLMNQW

Theoretical pI  9.24

Acidic residues  2

Basic residues  6

Polar residues  13

Molecular weight (Average)  3201.62

Molecular weight (Monoisotopic)  3199.46

Common amino acids  R

Net charge  4

Instability index (II)  127.08

Aliphatic index  38.57

Grand average of hydropathicity (GRAVY)  -0.636

Half Life 
  7.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 4720
  Abs 0.1% (=1 g/l) 1.474, assuming all pairs of Cys residues form cystines
  Ext. coefficient 4470
  Abs 0.1% (=1 g/l) 1.396, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN112010959A

Patent Title  Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.