Peptide Libraray

[R16A, R17A]GeXIVA[1,2]

General Information

DCTPep ID DCTPep06224

Peptide Name [R16A, R17A]GeXIVA[1,2]

Sequence TCRSSGRYCRSPYDRAARYCRRITDACV

Sequence Length 28

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Cancer targeted peptides α9α10nAChR inhibitor

Activity Information

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target α9α10nAChR

Affinity IC50=130 nM (Blocking α9α10nAChR)

Mechanism Specifically block the α9α10nAChR

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys2<--->Cys9; Cys20<--->Cys27

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C133H217N49O41S4

Absent amino acids EFHKLMNQW

Theoretical pI 9.57

Acidic residues 2

Basic residues 7

Polar residues 13

Molecular weight (Average) 3286.73

Molecular weight (Monoisotopic) 3284.53

Common amino acids R

Net charge 5

Instability index (II) 97.44

Aliphatic index 35.00

Grand average of hydropathicity (GRAVY) -0.861

Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 4720
Abs 0.1% (=1 g/l) 1.436, assuming all pairs of Cys residues form cystines
Ext. coefficient 4470
Abs 0.1% (=1 g/l) 1.360, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID CN112010959A

Patent Title Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof

Other Iinformation Not available

Other Published ID Not available