This work is licensed under a Creative Commons Attribution 4.0 International License.
Δ6-22GeXIVA
General Information
DCTPep ID DCTPep06228
Peptide Name Δ6-22GeXIVA
Sequence GRYCRSPYDRRRRYCRR
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Cancer targeted peptides α9α10nAChR inhibitor
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α9α10nAChR
Affinity IC50=14 nM (Blocking α9α10nAChR)
Mechanism Specifically block the α9α10nAChR
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys15
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C95H155N41O24S2
Absent amino acids AEFHIKLMNQTVW
Theoretical pI 11.24
Acidic residues 1
Basic residues 8
Polar residues 7
Molecular weight (Average) 2319.66
Molecular weight (Monoisotopic) 2318.16
Common amino acids R
Net charge 7
Instability index (II) 196.51
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -2.424
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 4595
Abs 0.1% (=1 g/l) 1.981, assuming all pairs of Cys residues form cystines
Ext. coefficient 4470
Abs 0.1% (=1 g/l) 1.927, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN112010960A
Patent Title Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.