1t-GeXIVA

General Information


DCTPep ID  DCTPep06255

Peptide Name   1t-GeXIVA

Sequence  tCRSSGRYCRSPYDRRRRYCRRITDACV

Sequence Length  28

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Cancer targeted peptides α9α10nAChR inhibitor



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  α9α10nAChR

Affinity  IC50=24.7 nM (Blocking α9α10nAChR)

Mechanism  Specifically block the α9α10nAChR



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys2<--->Cys9; Cys20<--->Cys27

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID CN112010972A

Patent Title  Novel alpha O-conotoxin peptide GeXIVA new mutant as well as pharmaceutical composition and application thereof

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.