TRAIL225-232

General Information


DCTPep ID  DCTPep06818

Peptide Name   TRAIL225-232

Sequence  SARNSCWS

Sequence Length  8

UniProt ID  P50591 

PubChem CID  Not available

Origin  TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand)

Type  Synthetic peptide

Classification

  

Cell death inducible peptide



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Induce cell death



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C36H55N13O13S1

Absent amino acids  DEFGHIKLMPQTVY

Theoretical pI  7.96

Acidic residues  0

Basic residues  1

Polar residues  5

Molecular weight (Average)  909.97

Molecular weight (Monoisotopic)  909.38

Common amino acids  S

Net charge  1

Instability index (II)  94.53

Aliphatic index  12.50

Grand average of hydropathicity (GRAVY)  -0.875

Half Life 
  1.9 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 6.044, assuming all pairs of Cys residues form cystines
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 6.044, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 16427631

Title  High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence

Doi 10.1016/j.febslet.2006.01.010

Year  2006

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.