This work is licensed under a Creative Commons Attribution 4.0 International License.
TRAIL227–234
General Information
DCTPep ID DCTPep06819
Peptide Name TRAIL227–234
Sequence RNSCWSKD
Sequence Length 8
UniProt ID P50591
PubChem CID Not available
Origin TRAIL (Tumor necrosis factor-related apoptosis-inducing ligand)
Type Synthetic peptide
Classification
Cell death inducible peptide
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Induce cell death
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C40H62N14O14S1
Absent amino acids AEFGHILMPQTVY
Theoretical pI 8.22
Acidic residues 1
Basic residues 2
Polar residues 4
Molecular weight (Average) 995.08
Molecular weight (Monoisotopic) 994.43
Common amino acids S
Net charge 1
Instability index (II) 94.53
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -1.925
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 5.527, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 5.527, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16427631
Title High-throughput screening of cell death inducible short peptides from TNF-related apoptosis-inducing ligand sequence
Doi 10.1016/j.febslet.2006.01.010
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.