This work is licensed under a Creative Commons Attribution 4.0 International License.
TRAIL227–234[N2C]
General Information
DCTPep ID DCTPep06821
Peptide Name TRAIL227–234[N2C]
Sequence RCSCWSDK
Sequence Length 8
UniProt ID Not available
PubChem CID Not available
Origin TRAIL227–234
Type Synthetic peptide
Classification
Cell death inducible peptide
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Induce cell death
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C39H61N13O13S2
Absent amino acids AEFGHILMNPQTVY
Theoretical pI 8.06
Acidic residues 1
Basic residues 2
Polar residues 4
Molecular weight (Average) 984.11
Molecular weight (Monoisotopic) 983.4
Common amino acids CS
Net charge 1
Instability index (II) 68.49
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -1.175
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5625
Abs 0.1% (=1 g/l) 5.716, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 5.589, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17822671
Title Screening of a novel octamer peptide, CNSCWSKD, that induces caspase-dependent cell death
Doi 10.1016/j.bbrc.2007.08.110
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.