TRAIL227–234[S3N]

General Information


DCTPep ID  DCTPep06825

Peptide Name   TRAIL227–234[S3N]

Sequence  RNNCWSKD

Sequence Length  8

UniProt ID  Not available

PubChem CID  Not available

Origin  TRAIL227–234

Type  Synthetic peptide

Classification

  

Cell death inducible peptide



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Induce cell death



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C41H63N15O14S1

Absent amino acids  AEFGHILMPQTVY

Theoretical pI  8.22

Acidic residues  1

Basic residues  2

Polar residues  4

Molecular weight (Average)  1022.1

Molecular weight (Monoisotopic)  1021.44

Common amino acids  N

Net charge  1

Instability index (II)  50.17

Aliphatic index  0.00

Grand average of hydropathicity (GRAVY)  -2.263

Half Life 
  1 hours (mammalian reticulocytes, in vitro).
  2 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 5.381, assuming all pairs of Cys residues form cystines
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 5.381, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17822671

Title  Screening of a novel octamer peptide, CNSCWSKD, that induces caspase-dependent cell death

Doi 10.1016/j.bbrc.2007.08.110

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.