Peptide Libraray

SALF

General Information

DCTPep ID DCTPep06828

Peptide Name SALF

Sequence ECKFTVKPYLKRFQVYYKGRMWCP

Sequence Length 24

UniProt ID Not available

PubChem CID Not available

Origin Penaeus monodon

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane lysis Induce apoptosis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HeLa	Human papillomavirus-related endocervical adenocarcinoma	65% Inhibition=100μg/ml	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism SALF can induce apoptotic gene expressions, enhance antitumor activity of cisplatin in vitro, and inhibit tumor growth in nude mice.

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys2<--->Cys23

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C145H216N36O32S3

Absent amino acids ADHINS

Theoretical pI 9.70

Acidic residues 1

Basic residues 6

Polar residues 7

Molecular weight (Average) 3071.71

Molecular weight (Monoisotopic) 3069.55

Common amino acids K

Net charge 5

Instability index (II) 36.94

Aliphatic index 40.42

Grand average of hydropathicity (GRAVY) -0.667

Half Life
1 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 10095
Abs 0.1% (=1 g/l) 3.286, assuming all pairs of Cys residues form cystines
Ext. coefficient 9970
Abs 0.1% (=1 g/l) 3.246, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 20214941

Title Shrimp anti-lipopolysaccharide factor peptide enhances the antitumor activity of cisplatin in vitro and inhibits HeLa cells growth in nude mice

Doi 10.1016/j.peptides.2010.02.023

Year 2010

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available