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GE18
General Information
DCTPep ID DCTPep06829
Peptide Name GE18
Sequence GAGIVVASIDTGVRVSHE
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Virulence factor of aquatic pathogenic fungus Aphanomyces invadans
Type Native peptide
Classification
ACP Tumor active peptide Induce apoptosis
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | IC50=29.06μM | MTT assay | 48h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=35.34μM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Rat skeletal myoblast cell line (L6): 91.73 ± 2% viability = 10 µM; 90.65 ± 2.9% viability = 20 µM; 87.91 ± 3.05% viability = 30 µM; 87.29 ± 1.9% viability = 40 µM; 84.44 ± 3.8% viability = 50 µM
Target Not available
Affinity Not available
Mechanism GE18 affects the cellular morphology, which triggers the cells to undergo apoptosis for biological cellular elimination
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Amidation
C-terminal Modification Acetylation
Other Modification None
Chiral L
Physicochemical Information
Formula C75H127N23O26
Absent amino acids CFKLMNPQWY
Theoretical pI 5.32
Acidic residues 2
Basic residues 2
Polar residues 6
Molecular weight (Average) 1766.97
Molecular weight (Monoisotopic) 1765.93
Common amino acids V
Net charge 0
Instability index (II) -17.77
Aliphatic index 118.89
Grand average of hydropathicity (GRAVY) 0.622
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 37764521
Title Aquatic Peptide: The Potential Anti-Cancer and Anti-Microbial Activity of GE18 Derived from Pathogenic Fungus Aphanomyces invadans
Year 2023
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.