Peptide Libraray

Iturin A

General Information

DCTPep ID DCTPep06833

Peptide Name Iturin A

Sequence NynQPnS

Sequence Length 7

UniProt ID Not available

PubChem CID Not available

Origin Bacillus subtilis

Type Native peptide

Classification

Induce apoptosis Lipopeptide Amphiphilic

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
HepG2	Hepatoblastoma	10% viability=75μM	MTT assay	48h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Iturin A significantly inhibited the growth of tumor cells, induce apoptosis, autophagy and paraptosis.

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification β-amino fatty acid with a-(CH2)10CH3 group

Other Modification None

Chiral Mix

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33970365

Title Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo

Doi 10.1186/s13568-021-01226-4

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available