This work is licensed under a Creative Commons Attribution 4.0 International License.
General Information
DCTPep ID DCTPep06872
Peptide Name
Sequence IWDTIEK
Sequence Length 7
UniProt ID Not available
PubChem CID 14389340
Origin Snake venom of N. kaouthia
Type Native peptide
Classification
Cancer targeted peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target EGFR
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C42H65N9O13
Absent amino acids ACFGHLMNPQRSVY
Theoretical pI 4.37
Acidic residues 2
Basic residues 1
Polar residues 1
Molecular weight (Average) 904.03
Molecular weight (Monoisotopic) 903.47
Common amino acids I
Net charge -1
Instability index (II) 49.87
Aliphatic index 111.43
Grand average of hydropathicity (GRAVY) -0.500
Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 6.084
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 37293380
Title Proteome of monocled cobra ( Naja kaouthia) venom and potent anti breast cancer peptide from trypsin hydrolyzate of the venom protein
Doi 10.1016/j.jsps.2023.04.001
Year 2023
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.